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451 is invalid or DNS says does not exist

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Employee is getting NDR when sending to one company.  Her email works fine to other companies.  Message Tracking shows 451 <FrontEndExchangeServer.domain.com> is invalid or DNS says does not exist.  Their ServerIp and ServerHostname matches with the test we did with mxtoolbox.  The recipient was able to receive a test email from a test hotmail account.

Using is seeing in NDR

#550 4.4.7 QUEUE.Expired;
message expired ##


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